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CAS No.: 544-31-0

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Chemical Name: Palmitoylethanolamide

Molecular Formula: C18H37NO2

Formula Weight: 299.49

CAS No.: 544-31-0

Palmitoylethanolamide Usage And Synthesis

Description Palmitoylethanolamide (PEA) is a fatty acid amide produced in the body that binds to and activates the peroxisome proliferator-activated receptor alpha (PPAR-α). It was initially described as an agonist to the type 2 cannabinoid receptor (CB2), though it is now recognized that PEA does not bind to cannabinoid receptors. PEA is known to have anti-inflammatory, analgesic, and neuroprotective properties. PEA supplements have been used by people with chronic pain as well as those with neuropathic pain.

Chemical Properties Palmitoylethanolamide is a natural occurring lipid belonging to the class of autacoids. It is a fine white to yellow powder. PEA consists of palmitic acid and ethanolamine. It is the hydrolyzed form of N-(2-hydroxyethyl)-palmitamide, a crystalline structure isolated in soy lecithin. It is this hydrolyzed substance that accounts for the anti-inflammatory properties that were first noted by scientists in 1957. PEA’s effects on the immune system have been studied since 1939.

Uses Palmitoylethanolamide is a natural substance produced by the body and it is very effective and safe to use as a supplement for pain and reduce inflammation.
PEA can be synthesized within the human body from the abundant fatty acid palmitic acid, but it is not dependent or influenced by dietary consumption of fatty acids. Palmitic acid in the diet is derived from dairy products such as cheese and butter, palm tree oil, and animal meat products. However, increasing palmitic acid in the hope of increasing endogenous PEA synthesis will not be effective.

The anti-inflammatory properties of PEA are due to its ability to inhibit inflammation-causing proteins called cytokines. Cytokines are released during periods of inflammation. PEA can suppress the secretion of tumor necrosis factor alpha (TNF alpha), a cytokine, while also inhibiting the release of interleukins. Interleukins are a specific class of cytokines which belong in the immunological system and are activated during the process of inflammation.
Chronic Pain and the Use of Palmitoylethanolamide: An Update
Definition ChEBI: Palmitoylethanolamide is an N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant. It is a N-(long-chain-acyl)ethanolamine, an endocannabinoid and a N-(saturated fatty acyl)ethanolamine. It is functionally related to a hexadecanoic acid.

CAS No.: 544-31-0
Molecular Formular: C18H37NO2
Molecular Weight: 299.5
Country of Origin: S S. China
Item Specification Test Method
Active Ingredients
Assay(%, On Dried base) NLT98.0% GC
Physical Control
Appearance Fine Powder Visual
Color White to Off-White Visual
Identification Positive IR&1H NMR
Loss on Drying 1.0% Max CPh
Residue on ignition 0.1% Max CPh

Particle size

D(0.5): 3μm PCS
D(0.99): 10μm PCS
Excipients None /
Chemical Control
Heavy Metals NMT10 ppm CPh
Arsenic(As2O3) NMT1ppm CPh
Sulfate(SO4) NMT0.040% CPh
Iron(Fe) NMT10 ppm CPh
Chloride(Cl) NMT 0.020% CPh
Solvent Residual Meeting USP Standard GC
Microbiological Control
Total Plate Count 1,000cfu/g Max USP
Yeast & Mold 100cfu/g Max USP
Coliforms 10cfu/g Max BAM
E.Coli Negative/10g USP
Salmonella sp. Negative/25g USP
Staph Aureus Negative/10g USP
Pseudomonas aeruginosa Negative/25g USP
Packing and Storage
Packing Pack in paper-drums and two plastic bags inside. 25 Kg/Drum
Storage Store in a well-closed container away from moisture and direct sunlight.
Shelf Life 2 years if sealed and stored properly.


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